Skip to main content
. Author manuscript; available in PMC: 2013 Feb 13.
Published in final edited form as: Science. 2010 Jun 4;328(5983):1288–1290. doi: 10.1126/science.1186909

Fig. 1.

Fig. 1

BDNF infused into the infralimbic cortex substitutes for behavioral extinction. (A) Rats’ freezing levels in response to tones that were paired with footshocks (Cond) or given alone during extinction (Ext) and Test sessions. BDNF infusions into the IL mPFC before extinction (arrow) reduced freezing on days 2 and 3 relative to saline-infused (SAL) controls (n = 8 per group). (B) A similar effect was observed when BDNF was infused in the absence of training on day 2 (SAL, n = 5; BDNF, n = 7). (C) Infusing BDNF 24 hours before conditioning had no effect (SAL, n = 9; BDNF, n = 7). Trials are shown in blocks of two. **P < 0.01, repeated-measures analysis of variance (ANOVA). Error bars represent SEM.