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. 2013 Feb 13;3:1256. doi: 10.1038/srep01256

Figure 1. Copper affects the propensity for Aβ42 to form ThT-positive β sheets.

Figure 1

(a) The influence of the metal:peptide ratio on the ThT fluorescence of Aβ42 (8.0 μM) after incubation at 37°C for 1, 3 and 24 h. Mean and SD are plotted, n = 4. (b) The influence of sub-, equimolar and super-stoichiometric concentrations of Cu(II) on the ThT fluorescence of Aβ42 (5.0 μM) after incubation at 37°C for 24 h. Mean and SD are plotted, n = 3. (c) Abolition by 100 μM EDTA of the effects of sub- to equimolar concentrations of Cu(II) on the ThT fluorescence of Aβ42 (5.0 μM) after incubation at 37°C for 24 h. Mean and SD are plotted, n = 3. (d) The influence of the concentration of Aβ42 on the propensity for Cu(II) at a metal:peptide ratio of 0.5 to form ThT-positive β sheets. Mean and SD are plotted, n = 3.