Figure 2. Copper abolishes the negatively-stained fibrillar structure of Aβ₄₂ as viewed by TEM.

(a) An 8.0 μM preparation of Aβ₄₂ incubated for 3 h at 37°C under near-physiological conditions assembles into negatively stained amyloid single and double fibrils. (b) An 8.0 μM preparation of Aβ₄₂ in the presence of 80 μM Cu(II) incubated for 3 h at 37°C under near-physiological conditions forms amorphous positively stained deposits showing remnants of a fibril-like morphology. Scale bar 200 nm for both TEM images.