TABLE 2.
Best-Fit Parameter Values (and 95% Confidence Intervals) for all Analyzed Tumor Types
| Tumor type | Data | 108 × a day−2 | 102 × b day−1 | 106 × c day−2 | L day |
|---|---|---|---|---|---|
| All solid tumors | Mortality | 1.42 (0.9, 2.1) | 1.59 (1.2, 2.1) | 6.54 (4.5, 8.5) | 200 |
| Bone | Incidence | – | 1.59 (0.6, 2.2) | – | 100 |
| Liver | Incidence | – | 1.59 (1.1, 2.3) | – | 100 |
| Lung | Incidence | – | 1.59 (1.1, 2.7) | – | 100 |
| Pituitary | Incidence | – | 1.59 (1.1, 2.5) | – | 100 |
| Tumor type | 104 × δ day−1 | X day × Gy−1 | Y Gy−1 | X/Y days | α Gy−1 |
|---|---|---|---|---|---|
| All solid tumors | 2.11 (0.2, 3.9) | 79.7 (20, 250) | 12.2 (0.1, 170) | 6.5 | 0.60 (0.3, 1.1) |
| Bone | 2.11 (0.5, 7.6) | 79.7 (22, 340) | 1.99 (0.2, 15) | 40 | 0.20 (0.1, 0.5) |
| Liver | 2.11 (0.2, 12) | 79.7 (53, 160) | 0.596 (0.3, 4.6) | 130 | 0.273 (0.1, 0.6) |
| Lung | 2.11 (0.5, 5.5) | 79.7 (5.0, 950) | 1.77 (0.1, 25) | 45 | 0.60 (0.4, 0.9) |
| Pituitary | 2.11 (0.3, 8.4) | 79.7 (56, 130) | 0.459 (0.2, 2.6) | 170 | 0.283 (0.0, 0.8) |
Notes. Parameter interpretations and restrictions are listed in Table 1. The ratio X/Y is shown for easier comparison of initiation/promotion balance between different cancer sites; it is not a model parameter.