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. 2012 Nov 27;79(22):2194–2200. doi: 10.1212/WNL.0b013e31827595e2

Figure 4. Functional expression of wild-type CLC-1 and W118G in cells.

Figure 4

Functional expression of wild-type ClC-1 and the W118G mutation by whole cell patch clamp of transfected HEK293T cells. (A) Representative wild-type recording. (B) Representative mutant recording. (C) Boltzmann fits of the normalized tail current from 6 wild-type (squares) and 4 mutant (triangles) recordings to show the similar voltage dependence of activation. Error bars are obscured by symbol. (D) V50 and slope (with 95% confidence intervals) from the Boltzmann fits.