Table 2.

Primary and Secondary Outcome Measures in Subgroups with Glucose Concentration Below or Above 7 before Breakfast in Closed Loop^a

Start glucose < 7 mmol/liter (n = 4)	OL	CL	p value
Venous blood values (mean mmol/liter)
Overall	8.8 (7.9–9.7)	8.1 (6.4–9.9)	0.59
Postprandial breakfast	9.7 (6.3–12.5)	9.8 (7–12.3)	0.9
Postexercise	7.2 (5.5–9.3)	8.6 (5.5–13.1)	0.43
Postprandial lunch	8.9 (6.4–12.6)	7.2 (5.5–8.7)	0.41

Sensor glucose values (mean mmol/liter/min)
Overall	-0.2 (-2.1–2.1)	3.7 (2.2–5.1)	0.053
Postprandial breakfast	1.3 (0.7–2.2)	5.3 (2.8–8.7)	0.04
Postexercise	-2.6 (-4.4– -0.6)	-2.5 (-4.7–0.4)	0.83
Postprandial lunch	2.4 (1–5.2)	0.03 (-1.6–1.9)	0.10

Insulin administration (IU)
Overall	25.2 (15.2–42.7)	40.4 (14.1–86.6)	0.27
Postprandial breakfast	9.2 (4.1–20)	25.7 (3.5–58.3)	0.14
Postexercise	2 (1.3–2.5)	4.1 (1–8.5)	0.27
Postprandial lunch	14.1 (8.7–20.2)	10.7 (6.3–19.8)	0.07
Hypoglycemic events	1	2

Start glucose > 7 mmol/liter (n = 6)
Venous blood values (mean mmol/liter)
Overall	9.2 (5.4–13.5)	9.2 (7.3–11)	1.0
Postprandial breakfast	9.4 (4.3–13.3)	12.5 (9.5–16.2)	0.045
Postexercise	7.6 (4.6–13)	7.9 (5.7–10.5)	0.82
Postprandial lunch	9.7 (6–14.9)	8 (6.7–9)	0.31

Sensor glucose values (mean mmol/liter/min)
Overall	0.6 (-1.5–3.3)	0.2 (-1.8–2.1)	0.68
Postprandial breakfast	1.7 (-0.4–3.6)	4 (2.5–6.6)	0.03
Postexercise	-1.9 (-4.7–0.3)	-6.3 (-11.2– -2.8)	0.001
Postprandial lunch	2.6 (-0.9–6.2)	2.5 (1–4.3)	0.9

Insulin administration (IU)
Overall	24 (10.8–45.6)	37.3 (22.4–65.6)	0.03
Postprandial breakfast	8.2 (4.3–11.6)	21.8 (10.3–28.8)	0.03
Postexercise	2 (0.7–4.9)	2.2 (0.5–8.8)	0.5
Postprandial lunch	13.8 (5.6–29.5)	13.4 (6.3–28.3)	0.6
Hypoglycemic events	1	2

^aNumbers are given as mean with range (minimum and maximum).