Table 1.
Glucose Diffusivity and Sensor Characteristics
| Material | Condition | Diffusivitya (cm2/s) |
Baseline Lifetimeb τzero (µs) |
Total Percentage Changec (0–400 mg/dl) |
Maximum Sensitivityd (%/s) |
Analytical Rangee (mg/dl) |
|---|---|---|---|---|---|---|
| pHEMA | Untreated | (8.1 ± 0.38) ×10-8 (n = 3) |
18.5 | 589 ± 68.9 (n = 7) |
2.5 at 4 mg/dl | [4.2, 356] |
| Serum-exposed | (3.5 ± 0.43) ×10-8 (n = 3) |
17.3 | 384 ± 70.8 (n = 4) |
2.7 at 6.6 mg/dl | [6.6, 317] | |
| p(HEMA-coAM) | Untreated | (2.5 ± 0.08) ×10-6 (n = 3) |
13.9 | 493 ± 55.0 (n = 4) |
14.9 at 52mg/dl | [17.6, 70.5] |
| Serum-exposed | (1.6 ± 0.16) ×10-6 (n = 3) |
14.1 | 544 ± 88.5 (n = 3) |
8.9 at 67 mg/dl | [18.1, 107.2] | |
| pAMf | Untreated | (2.7 ± 0.15) ×10-6 (n = 3) |
– | – | -– | – |
| Serum-exposed | (1.4 ± 0.11) ×10-6 (n = 3) |
– | – | – | – |
a
Calculated from nonsensing slabs in Side-bi-Side cells at 1-week serum exposure; errors represent 95% confidence.
b
Luminescence lifetime value of sensor slab at 0 mg/dl glucose concentration in air-equilibrated PBS.
c
Errors represent standard deviations between separate hydrogel sensor slabs.
d
Maximum sensitivity represents the highest slope of the response curve. Locations of maximum sensitivity given in concentration of glucose (mg/dl).
e
Range displayed as lower and upper limits in brackets: [lower limit, upper limit].
f
Repeatable response data could not be obtained from pAM sensor gels due to signal instability and therefore are not shown.