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Hyperglycemic rebound with existing integrator windup protection rules23 (blue solid curve, worst case subject 7) compared with rebound obtained with modified rules (see text). Hypoglycemia was avoided with the modified rules (nadir BG 57 versus 61 mg/dl, unmodified versus modified). Responses included a meal (100 g at 07:00 h) and a 30% increase in insulin sensitivity during night (starting at 22:00 h)
