Table 1.
ErbB molecules and their ligands and adaptors/effectors.
| ErbB receptor | Nomenclature | Binding partner | Ligand | Major signaling molecules | Other binding proteins | |
|---|---|---|---|---|---|---|
| ErbB1 | EGF receptor (EGFR), HER1 | ErbB1 | EGF | EPG | PI3K-AKT | Cbl |
| ErbB2 | TGFα | EPR | Ras-MAPK | STAT3 | ||
| ErbB3 | HB-EGF | PLCγ-PKC | ||||
| ErbB4 | AR | Crk FAK JAK | ||||
| BTC | Src PTEN | |||||
| ErbB2 | Neu, HER2 | ErbB1 | Unknown | PI3K-AKT | Erbin | |
| ErbB3 | Ras-MAPK | |||||
| ErbB4 | FAK Src | |||||
| ErbB3 | HER3 | ErbB1 | NRG1 | PI3K-AKT | Cbl | |
| ErbB2 | NRG2 | Ras-MAPK | EBP1 | |||
| ErbB4 | NRG6 | PLCγ-PKC | TENC1 | |||
| Crk ITK JAK Lyn Src VAV | ||||||
| ErbB4 | HER4 | ErbB1 | HB-EGF | NRG2 | PI3K-AKT | N-Cor |
| ErbB2 | BTC | NRG3 | Ras-MAPK | PSD95 | ||
| ErbB3 | EPG | NRG4 | JAK Src Ptprz | STAT5 | ||
| ErbB4 | NRG1 | NRG5 | TAB2 | |||