Table 2.
Gene | Treatment | Site | MESOR | Amplitude | Acrophase (h) |
---|---|---|---|---|---|
Bmal1 | Sham | Atrium | 4.0 ± 0.1§* | 5.4 ± 0.1§*# | 23.2 ± 0.3 |
Ventricle | 1.2 ± 0.1§*# | 1.7 ± 0.1§*# | 23.2 ± 0.2 | ||
SCNX | Atrium | 2.9 ± 0.3§ | 1.5 ± 0.2§ | N/A | |
Ventricle | 0.7 ± 0.1§ | 0.4 ± 0.1§ | N/A | ||
ANSB | Atrium | 3.8 ± 0.2§ | 2.2 ± 0.3§ | 22.5 ± 0.1 | |
Ventricle | 0.9 ± 0.1§ | 0.4 ± 0.1§ | 22.1 ± 0.4 | ||
Per2 | Sham | Atrium | 2.8 ± 0.3 | 2.5 ± 0.1§*# | 12.8 ± 0.4 |
Ventricle | 0.6 ± 0.1 | 0.5 ± 0.1§*# | 12.6 ± 0.3# | ||
SCNX | Atrium | 2.0 ± 0.2 | 1.3 ± 0.2§ | N/A | |
Ventricle | 0.6 ± 0.1 | 0.3 ± 0.1§ | N/A | ||
ANSB | Atrium | 2.6 ± 0.4 | 0.9 ± 0.4§ | 11.5 ± 1.2 | |
Ventricle | 0.7 ± 0.1 | 0.04 ± 0.01§ | 7.2 ± 2.3 | ||
Dbp | Sham | Atrium | 5.8 ± 0.3§*# | 7.2 ± 0.6§*# | 9.9 ± 0.2 |
Ventricle | 1.9 ± 0.1§*# | 2.2 ± 0.2§*# | 9.9 ± 0.3# | ||
SCNX | Atrium | 3.6 ± 0.4§ | 2.1 ± 0.4§ | N/A | |
Ventricle | 1.0 ± 0.1§ | 0.5 ± 0.1§γ | N/A | ||
ANSB | Atrium | 2.7 ± 0.2§ | 2.4 ± 0.4§ | 8.0 ± 0.4 | |
Ventricle | 1.3 ± 0.1§ | 1.5 ± 0.1§ | 6.6 ± 0.1 |
Note: Data are mean ± SEM for 3–6 mice per group. MESOR, midline estimating statistic of rhythm; Sham, sham-operated; SCNX, suprachiasmatic nucleus lesioned; ANSB, autonomic nervous system block; N/A, not applicable.
One-way ANOVA p < 0.05, Bonferroni/Dunn, p < 0.05.
Sham vs. lesion;
Sham vs. ANSB;
Lesion vs. ANSB.