Simplified flow chart of Hsp70 impact on ATP generation. High expression levels of Hsp70 in heat-shocked HeLa cells led to a shift in energy metabolism with increased anaerobic glycolysis and attenuated oxidative phosphorylation. Therefore, under challenging environmental conditions, the danger of potential, harmful release of reactive oxygen species (ROS) in mitochondria is diminished. F-1,6-P, fructose 1,6-bisphosphate; CoA, coenzyme A.