. Author manuscript; available in PMC: 2013 Feb 13.

Published in final edited form as: J Clin Pharmacol. 2009 Oct 19;50(1):62–72. doi: 10.1177/0091270009337946

Table 3.

Escitalopram pharmacokinetic parameter from final model

Parameters	Final Model Estimates	SE%
CL for 2C19 Rapid and Extensive (L/Hr)	26	7.20%
CL for 2C19 IM and PM (L/Hr)	19.8	8.50%
CL for 2C19 missing (L/Hr)	21.5	7.80%
Age on Clearance	CL₁=CL₀*(Age/40) ^−0.336	42.00%
Weight on Clearance	CL₂=CL₁*(Wgt/76) ^0.333	54.10%
V (L)	947	10.20%
BMI on V	V*(BMI/27) ^1.11	49.50%
Ka (hr⁻¹)	0.8	N/A
ω_cl %	48.5%	15.10%
ω_v %	62.0%	40.30%
ω_Ka %	78.9%	87.00%
ω_cl,v %	9.4%	N/A
ω_cl,Ka %	47.8%	N/A
ω_V,Ka %	81.3%	N/A
σ₁ %	28.9%	8.80%

CL, clearance; V, volume of distribution; SE, standard error; ω, coefficient of variation of inter-individual variability; σ, coefficient of variation of residual error