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. Author manuscript; available in PMC: 2013 Feb 13.
Published in final edited form as: J Clin Pharmacol. 2009 Oct 19;50(1):62–72. doi: 10.1177/0091270009337946

Table 4.

Post-processed individual empirical Bayes estimates on clearance

Population Mean Clearance
(L/Hr)
Standard Deviation
(L/Hr)
P
value
Genotype information <0.005
 Rapid and Extensive (n=82) 29.73 13.13
 IM and PM (n=46) 22.23 11.04
 Missing (n=44) 23.41 10.65
Age <0.005
 < 30 years old (n=45) 31.03 14.88
 30~50 years old (n=84) 25.71 11.31
 50~65 years old (n=43) 21.74 9.89
Clinical Trial Location <0.001
 Pittsburgh patients (n=105) 28.55 13.54
 Pisa patients (n=67) 22.28 9.32