Table 3.

Mediation Analysis for the Association Between HNF1B (rs7501939) and Prostate Cancer With Diabetes Phenotype as a Potential Intermediate in the Breast and Prostate Cancer Cohort Consortium^a

	Odds Ratio	95% Confidence Interval	P Value
HNF1B-T2D association	1.10	0.97, 1.25	0.14
T2D-prostate cancer association	0.76	0.66, 0.87	8.13 × 10−05
Natural indirect effect	1.00	1.00, 1.00	0.71
Natural direct effect	0.83	0.79, 0.86	1.02 × 10−18
Total effect	0.83	0.79, 0.86	6.37 × 10−19

Abbreviation: T2D, type 2 diabetes.

^a All analyses were conducted in the Breast and Prostate Cancer Cohort Consortium and were adjusted for cohort indicator, age at baseline (years), and body mass index (weight (kg)/height (m)²).