Table 3.
Odds Ratio | 95% Confidence Interval | P Value | |
---|---|---|---|
HNF1B-T2D association | 1.10 | 0.97, 1.25 | 0.14 |
T2D-prostate cancer association | 0.76 | 0.66, 0.87 | 8.13 × 10−05 |
Natural indirect effect | 1.00 | 1.00, 1.00 | 0.71 |
Natural direct effect | 0.83 | 0.79, 0.86 | 1.02 × 10−18 |
Total effect | 0.83 | 0.79, 0.86 | 6.37 × 10−19 |
Abbreviation: T2D, type 2 diabetes.
a All analyses were conducted in the Breast and Prostate Cancer Cohort Consortium and were adjusted for cohort indicator, age at baseline (years), and body mass index (weight (kg)/height (m)2).