Table 1.
No Hodgkin Lymphoma (n = 3,570,631) |
Any Hodgkin Lymphoma (n = 943) |
Nodular Sclerosis (n = 572) |
Mixed Cellularity (n = 76) |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
No. | % | Mean (SD) | No. | % | Mean (SD) | No. | % | Mean (SD) | No. | % | Mean (SD) | |
Age at diagnosis or last follow-up, years | ||||||||||||
0–4 | 465,765 | 13.0 | 13 | 1.4 | 1 | 0.2 | 3 | 3.9 | ||||
5–9 | 471,043 | 13.2 | 46 | 4.9 | 12 | 2.1 | 6 | 7.9 | ||||
10–14 | 444,955 | 12.5 | 120 | 12.7 | 57 | 10.0 | 6 | 7.9 | ||||
15–19 | 574,162 | 16.1 | 289 | 30.7 | 183 | 32.0 | 19 | 25.0 | ||||
20–24 | 520,730 | 14.6 | 271 | 28.7 | 172 | 30.1 | 29 | 38.2 | ||||
25–29 | 446,531 | 12.5 | 136 | 14.4 | 97 | 17.0 | 8 | 10.5 | ||||
≥30 | 647,445 | 18.1 | 68 | 7.2 | 50 | 8.7 | 5 | 6.6 | ||||
18.6 (10.4) | 20.2 (6.4) | 21.4 (5.9) | 19.7 (6.7) | |||||||||
Sex | ||||||||||||
Female | 1,735,532 | 48.6 | 454 | 48.1 | 327 | 57.2 | 20 | 26.3 | ||||
Male | 1,835,099 | 51.4 | 489 | 51.9 | 245 | 42.8 | 56 | 73.7 | ||||
Birth year | ||||||||||||
1973–1979 | 692,388 | 19.4 | 466 | 49.4 | 259 | 45.3 | 31 | 40.8 | ||||
1980–1984 | 455,025 | 12.7 | 237 | 25.1 | 158 | 27.6 | 20 | 26.3 | ||||
1985–1989 | 521,027 | 14.6 | 155 | 16.4 | 100 | 17.5 | 14 | 18.4 | ||||
1990–1994 | 581,676 | 16.3 | 67 | 7.1 | 43 | 7.5 | 8 | 10.5 | ||||
1995–1999 | 447,912 | 12.6 | 16 | 1.7 | 11 | 1.9 | 2 | 2.6 | ||||
2000–2004 | 460,980 | 12.9 | 1 | 0.1 | 1 | 0.2 | 0 | 0.0 | ||||
2005–2008 | 411,623 | 11.5 | 1 | 0.1 | 0 | 0.0 | 1 | 1.3 | ||||
Fetal growth, SD | ||||||||||||
<−2 | 112,411 | 3.1 | 29 | 3.1 | 18 | 3.1 | 1 | 1.3 | ||||
−2 to <−1 | 535,680 | 15.0 | 137 | 14.5 | 82 | 14.3 | 9 | 11.8 | ||||
−1 to <0 | 1,266,450 | 35.5 | 350 | 37.1 | 206 | 36.0 | 31 | 40.8 | ||||
0 to <1 | 1,118,520 | 31.3 | 277 | 29.4 | 171 | 29.9 | 17 | 22.4 | ||||
1 to <2 | 428,631 | 12.0 | 126 | 13.4 | 77 | 13.5 | 14 | 18.4 | ||||
≥2 | 108,939 | 3.1 | 24 | 2.5 | 18 | 3.1 | 4 | 5.3 | ||||
Birth weight, g | ||||||||||||
<2,500 | 149,333 | 4.2 | 26 | 2.8 | 18 | 3.1 | 0 | 0.0 | ||||
2,500–3,999 | 2,778,937 | 77.8 | 744 | 78.9 | 445 | 77.8 | 62 | 81.6 | ||||
≥4,000 | 642,361 | 18.0 | 173 | 18.3 | 109 | 19.1 | 14 | 18.4 | ||||
3,505 (574) | 3,539 (532) | 3,545 (544) | 3,600 (556) | |||||||||
Birth length, cm | ||||||||||||
<48 | 359,906 | 10.1 | 82 | 8.7 | 53 | 9.3 | 3 | 3.9 | ||||
48–52 | 2,600,677 | 72.8 | 680 | 72.1 | 408 | 71.3 | 53 | 69.7 | ||||
≥53 | 576,826 | 16.2 | 178 | 18.9 | 109 | 19.1 | 20 | 26.3 | ||||
Unknown | 33,222 | 0.9 | 3 | 0.3 | 2 | 0.3 | 0 | 0.0 | ||||
50.3 (2.5) | 50.5 (2.4) | 50.5 (2.4) | 51.0 (2.0) | |||||||||
Ponderal index, g × 100/cm3 | ||||||||||||
<2.60 | 1,015,895 | 28.5 | 284 | 30.1 | 173 | 30.2 | 27 | 35.5 | ||||
2.60–2.89 | 1,603,907 | 45.7 | 436 | 46.2 | 251 | 43.9 | 34 | 44.7 | ||||
≥2.90 | 890,607 | 24.9 | 220 | 23.3 | 146 | 25.5 | 15 | 19.7 | ||||
Unknown | 33,222 | 0.9 | 3 | 0.3 | 2 | 0.3 | 0 | 0.0 | ||||
2.74 (0.34) | 2.74 (0.40) | 2.74 (0.31) | 2.69 (0.24) | |||||||||
Gestational age at birth, weeks | ||||||||||||
22–28 | 10,966 | 0.3 | 1 | 0.1 | 1 | 0.2 | 0 | 0.0 | ||||
29–33 | 42,569 | 1.2 | 12 | 1.3 | 9 | 1.6 | 0 | 0.0 | ||||
34–36 | 153,255 | 4.3 | 41 | 4.3 | 19 | 3.3 | 6 | 7.9 | ||||
37–42 | 3,322,945 | 93.1 | 873 | 92.6 | 533 | 93.2 | 69 | 90.8 | ||||
≥43 | 40,896 | 1.1 | 16 | 1.7 | 10 | 1.7 | 1 | 1.3 | ||||
39.8 (1.9) | 40.0 (1.8) | 40.0 (1.9) | 39.8 (1.7) | |||||||||
Multiple birth status | ||||||||||||
Singleton | 3,486,171 | 97.6 | 928 | 98.4 | 562 | 98.3 | 75 | 98.7 | ||||
Twin | 84,460 | 2.4 | 15 | 1.6 | 10 | 1.7 | 1 | 1.3 | ||||
Birth order | ||||||||||||
1 | 1,499,457 | 42.0 | 415 | 44.0 | 246 | 43.0 | 32 | 42.1 | ||||
2 | 1,300,554 | 36.4 | 329 | 34.9 | 209 | 36.5 | 21 | 27.6 | ||||
3 | 541,362 | 15.2 | 150 | 15.9 | 90 | 15.7 | 17 | 22.4 | ||||
4 | 157,566 | 4.4 | 30 | 3.2 | 19 | 3.3 | 4 | 5.3 | ||||
≥5 | 71,692 | 2.0 | 19 | 2.0 | 8 | 1.4 | 2 | 2.6 | ||||
Maternal age at delivery, years | ||||||||||||
<20 | 84,076 | 2.4 | 29 | 3.1 | 14 | 2.4 | 5 | 6.6 | ||||
20–24 | 678,777 | 19.0 | 215 | 22.8 | 136 | 23.8 | 18 | 23.7 | ||||
25–29 | 1,252,859 | 35.1 | 368 | 39.0 | 219 | 38.3 | 26 | 34.2 | ||||
30–34 | 1,035,425 | 29.0 | 226 | 24.0 | 141 | 24.7 | 17 | 22.4 | ||||
35–39 | 432,834 | 12.1 | 90 | 9.5 | 53 | 9.3 | 8 | 10.5 | ||||
≥40 | 86,660 | 2.4 | 15 | 1.6 | 9 | 1.6 | 2 | 2.6 | ||||
Maternal education, years | ||||||||||||
≤9 | 674,982 | 18.9 | 217 | 23.0 | 135 | 23.6 | 20 | 26.3 | ||||
10–11 | 1,150,029 | 32.2 | 352 | 37.3 | 215 | 37.6 | 30 | 39.5 | ||||
12–14 | 1,045,276 | 29.3 | 213 | 22.6 | 129 | 22.5 | 15 | 19.7 | ||||
≥15 | 554,773 | 15.5 | 122 | 12.9 | 73 | 12.8 | 8 | 10.5 | ||||
Unknown | 145,571 | 4.1 | 39 | 4.1 | 20 | 3.5 | 3 | 3.9 | ||||
Paternal education, years | ||||||||||||
≤9 | 767,476 | 21.5 | 257 | 27.3 | 149 | 26.0 | 20 | 26.3 | ||||
10–11 | 1,129,000 | 31.6 | 269 | 28.5 | 166 | 29.0 | 28 | 36.8 | ||||
12–14 | 960,087 | 26.9 | 232 | 24.6 | 134 | 23.4 | 18 | 23.7 | ||||
≥15 | 537,994 | 15.1 | 143 | 15.2 | 97 | 17.0 | 9 | 11.8 | ||||
Unknown | 176,074 | 4.9 | 42 | 4.4 | 26 | 4.5 | 1 | 1.3 | ||||
Hodgkin lymphoma in a sibling | 1,222 | <0.1 | 5 | 0.5 | 4 | 0.7 | 0 | 0.0 | ||||
Hodgkin lymphoma in a parent | 3,699 | 0.1 | 8 | 0.8 | 5 | 0.9 | 1 | 1.3 |
Abbreviation: SD, standard deviation.