Table 5.
Subgroup of Medication Use | Observed No. of CVEs | Person-Years of Follow-up | Rate of Events per 1,000 Person- Years | Rate Ratio Adjusted for Agea | 95% CI | P Adjusted for Agea |
---|---|---|---|---|---|---|
Hydroxychloroquine useb | ||||||
Never | 46 | 2,570 | 17.9 | 1.00 | Referent | |
Past (not current) | 20 | 984 | 20.3 | 1.13 | 0.67, 1.91 | 0.65 |
Currently used but for <6 consecutive months | 14 | 827 | 16.9 | 1.02 | 0.56, 1.86 | 0.95 |
Current use for ≥6 consecutive months | 54 | 5,104 | 10.6 | 0.54 | 0.36, 0.79 | 0.0019 |
No. of prior months on hydroxychloroquine | ||||||
<12 | 26 | 1,594 | 16.3 | 0.58 | 0.40, 0.86 | 0.99 |
≥12 | 62 | 5,322 | 11.7 | 1.00 | 0.62, 1.62 | 0.0057 |
NSAID useb | ||||||
Never | 52 | 4,106 | 12.7 | 1.00 | Referent | |
Past (not current) | 46 | 2,761 | 16.7 | 1.17 | 0.69, 1.56 | 0.45 |
Current | 36 | 2,616 | 13.8 | 0.94 | 0.70, 1.60 | 0.78 |
No. of prior months on NSAIDs | ||||||
<12 | 21 | 2,129 | 9.8 | 1.21 | 0.83, 1.75 | 0.34 |
≥12 | 61 | 3,298 | 18.9 | 0.78 | 0.47, 1.30 | 0.32 |
Immunosuppresant useb | ||||||
Never | 56 | 4,646 | 12.1 | 1.00 | Referent | |
Past (not current) | 5 | 304 | 16.4 | 1.25 | 0.50, 3.13 | 0.63 |
Current | 73 | 4,535 | 16.1 | 1.43 | 1.01, 2.03 | 0.044 |
No. of prior months on immunosuppressants | ||||||
<12 | 17 | 862 | 19.7 | 1.92 | 1.11, 3.31 | 0.019 |
≥12 | 61 | 3,976 | 15.3 | 1.32 | 0.92, 1.90 | 0.13 |
Aspirin useb | ||||||
Never | 80 | 6,743 | 11.9 | 1.00 | Referent | |
Past (not current) | 22 | 1,160 | 19.0 | 1.5 | 1.0, 2.5 | 0.068 |
Current | 32 | 1,583 | 20.2 | 1.4 | 0.9, 2.1 | 0.11 |
No. of prior months on Aspirin | ||||||
<12 | 30 | 1,218 | 24.6 | 2.1 | 1.4, 3.3 | 0.0004 |
≥12 | 24 | 1,525 | 15.7 | 1.0 | 0.7, 1.6 | 0.89 |
Abbreviations: CI, confidence interval; CVE, cardiovascular event; NSAID, nonsteroidal anti-inflammatory drug.
a Age refers to the age of the patient at each month of follow-up.
b These do not include use of medications prior to cohort participation.