. 2012 Sep 27;176(8):708–719. doi: 10.1093/aje/kws130

Table 5.

Rates of Cardiovascular Events by Recent and Past Medication Use, Baltimore, Maryland, 1987–2010

Subgroup of Medication Use	Observed No. of CVEs	Person-Years of Follow-up	Rate of Events per 1,000 Person- Years	Rate Ratio Adjusted for Age^a	95% CI	P Adjusted for Age^a
Hydroxychloroquine use^b
Never	46	2,570	17.9	1.00	Referent
Past (not current)	20	984	20.3	1.13	0.67, 1.91	0.65
Currently used but for <6 consecutive months	14	827	16.9	1.02	0.56, 1.86	0.95
Current use for ≥6 consecutive months	54	5,104	10.6	0.54	0.36, 0.79	0.0019
No. of prior months on hydroxychloroquine
<12	26	1,594	16.3	0.58	0.40, 0.86	0.99
≥12	62	5,322	11.7	1.00	0.62, 1.62	0.0057
NSAID use^b
Never	52	4,106	12.7	1.00	Referent
Past (not current)	46	2,761	16.7	1.17	0.69, 1.56	0.45
Current	36	2,616	13.8	0.94	0.70, 1.60	0.78
No. of prior months on NSAIDs
<12	21	2,129	9.8	1.21	0.83, 1.75	0.34
≥12	61	3,298	18.9	0.78	0.47, 1.30	0.32
Immunosuppresant use^b
Never	56	4,646	12.1	1.00	Referent
Past (not current)	5	304	16.4	1.25	0.50, 3.13	0.63
Current	73	4,535	16.1	1.43	1.01, 2.03	0.044
No. of prior months on immunosuppressants
<12	17	862	19.7	1.92	1.11, 3.31	0.019
≥12	61	3,976	15.3	1.32	0.92, 1.90	0.13
Aspirin use^b
Never	80	6,743	11.9	1.00	Referent
Past (not current)	22	1,160	19.0	1.5	1.0, 2.5	0.068
Current	32	1,583	20.2	1.4	0.9, 2.1	0.11
No. of prior months on Aspirin
<12	30	1,218	24.6	2.1	1.4, 3.3	0.0004
≥12	24	1,525	15.7	1.0	0.7, 1.6	0.89

Abbreviations: CI, confidence interval; CVE, cardiovascular event; NSAID, nonsteroidal anti-inflammatory drug.

^a Age refers to the age of the patient at each month of follow-up.

^b These do not include use of medications prior to cohort participation.