Table 3.

Amino acid sequence similarity of selected M. leprae-specific proteins^a

Protein subclass	ORF	Molecular mass (kDa)	Sequence similarity (E value)	Mycobacterial protein(s) with amino acid sequence similarityb
VI.a	ML0070	9.1	None	NA
	ML0141	9.3	None	NA
	ML0448	10	None	NA
	ML0527	8.7	None	NA
	ML0574	11.4	None	NA
	ML0959	13.6	None	NA
	ML1010	8.4	None	NA
	ML1384	12.2	None	NA
	ML1575	11.1	None	NA
	ML2044	7.9	None	NA
	ML2651	11.6	None	NA
	ML2666	8.8	None	NA
VI.b	ML0121	9.6	3e−08	Hypothetical proteins of M. paratuberculosis
	ML0023	11.7	3e−06
	ML0188	9.2	3e−08	Conserved hypothetical unknown of M. paratuberculosis
	ML0217	8.4	1e−06
	ML0573	9.5	1e−05	Hypothetical protein of M. kansasii
	ML0588	8.5	3e−04	PPE protein of M. tuberculosis
	ML0953	8.6	1e−06	Putative nucleic acid binding protein of M. kansasii
VI.c	ML0614	10.2	3e−17	Hypothetical proteins of M. tuberculosis T46
	ML2630	13	7e−10	Conserved membrane protein of M. tuberculosis T92
	ML1949	12.5	5e−17	Hypothetical proteins of M. kansasii
VI.d	ML0755	9.6	1e−22	Hydrolase of M. kansasii
	ML0920	6.3	1e−102	Hypothetical protein of M. tuberculosis T17
	ML2307	9.3	4e−52	Transcription factor WhiB4 of M. paratuberculosis
	ML2313	21.8	3e−71	Transcriptional regulator (PadR) of M. avium 104

^aAll ORFs in subclass VI.a appear to have no homology. M. leprae proteins with BLASTP values between 1 × 10⁻⁴ and 1 × 10⁻⁸ are considered to have low homology (subclass VI.b). Proteins with E values between 1 × 10⁻⁸ and 1 × 10⁻²⁰ have moderate homology (subclass VI.c), and those with E values of <1 × 10⁻²⁰ have high homology (subclass VI.c).

^bMost similar one among several proteins found in BLASTP. NA, not applicable.