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Cell cycle arrest in antiproliferative activity of IFN. (A) WISH cells were transfected with cFLIP or caspase-8 siRNA followed by treatment with 1 nM YNS with or without Z-VAD for the indicated hours. Trypan blue staining was used to count live cells. (B) Cell cycle analysis was performed on WISH cells treated with 100 μM Z-VAD and/or 1 nM YNS for 48 h or left untreated (not treated [NT]).
