Table 1.
Clinical data and ex vivo ELISpot responses for study subjects
| Subject ID | HLA genotype | Viral load (RNA copies/ml) | CD4+ T count (cells/ml) | Time postinfection (mo) | Overlapping peptide responsea | Magnitudeb (SFU/106 PBMCs) | Protein | Optimal epitope tested | HLA restriction allele | Magnitude (SFU/106 PBMCs) | Protein |
|---|---|---|---|---|---|---|---|---|---|---|---|
| R035 | A*02:01/24:02 | 13,470 | 900 | 16 | PVGEIYKRWIILGLNKIV | 460 | Gag | VRHFPRIWL | B*27:05 | 165 | Vpr |
| B*27:05/44:02 | SILDIRQGPKEPFRDYV | 60 | Gag | ||||||||
| Cw*02:02/05:01 | KTVRLIKFLYQSNPPPS | 170 | Rev | ||||||||
| QARRNRRRRWRERQRQIR | 310 | Rev | |||||||||
| SLQYLALAALITPKKIK | 140 | Vif | |||||||||
| IKPPLPSVTKLTEDRWNK | 110 | Vif | |||||||||
| R039 | A*01:01/31:01 | 204 | 650 | 9 | WVKVVEEKAFSPEVIPMF | 535 | Gag | KAFSPEVIPMF | B*57:01 | 520 | Gag |
| B*27:05/57:01 | PVGEIYKRWIILGLNKIV | 615 | Gag | KRWIILGLNK | B*27:05 | 320 | Gag | ||||
| Cw*02:02/06:02 | LWVYHTQGYFPDWQNY | 235 | Nef | KRKGGIGGY | B*27:05 | 1,180 | Pol | ||||
| AVFIHNFKRKGGIGGYSA | 615 | Pol |
a
The characterized epitopes are underlined (data from the Los Alamos Immunology database, www.hiv.lanl.gov).
b
First ELISpot data available. SFU, spot-forming units.