Fig 7.

CVB3 infection depletes BM hematopoietic progenitors and causes a rise in serum Flt3L. BM cells were isolated at the indicated times after an i.p. wt CVB3 infection, and RBC lysis was performed. Total numbers and frequencies of Lin⁻ cells coexpressing the receptors Flt3 and c-kit were determined by flow cytometry. Dotplots shown in panel A are representative examples of each day of infection, and group data are shown (B). (C) Serum Flt3L levels were measured by ELISA. Data presented are from 2 (A and B) or 5 (C) experiments. (B and C) Means + standard errors are shown (*, 0.05 ≥ P > 0.01; **, 0.01 ≥ P > 0.001; ***, 0.001 ≥ P > 0.0001; ****, P ≤ 0.0001).