Fig 4.
VSV-MS immunization generates HBs-specific antibodies in HBV transgenic mice. Serum HBs-specific antibody titers in HBV transgenic mice prior to (pre) or 30 days after (post) intranasal immunization with 1 × 106 PFU of rWT VSV (n = 9) or VSV-MS (n = 9). Preimmunization antibody levels were not significantly different between the two groups (P > 0.05; Wilcoxon rank sum test). Each line connects the pre- and postimmunization values for a single animal. Statistical significance between pre- and postimmunization antibody titers was determined using the Wilcoxon signed-rank test.