Table 6.
Number of amino acid mutations in DENV 2 CD8+ T cell peptides across the DENV serotypes
| CD8+ peptidea | No. of amino acid mutations in DENV type: |
||
|---|---|---|---|
| 1 | 3 | 4 | |
| M 26 (126–140) | 2 | 3 | 1 |
| Env 21 (101–115) | 1 | 1 | 0 |
| Env 41 (201–215) | 2 | 3 | 2 |
| Env 83* (414–422) | 0 | 0 | 0 |
| Env 92 (456–470) | 2 | 2 | 2 |
| NS1 39 (191–205) | 2 | 2 | 1 |
| NS1 33 (161–175) | 2 | 2 | 4 |
| NS2A 6 (26–40) | 11 | 7 | 7 |
| NS2A 11 (51–65) | 4 | 4 | 4 |
| NS2B 22 (106–120) | 5 | 6 | 3 |
| NS3 18 (86–100) | 4 | 4 | 6 |
| NS3 27* (133–143) | 1 | 1 | 1 |
| NS3 41 (201–215) | 1 | 1 | 2 |
| NS3 45* (221–232) | 2 | 0 | 0 |
| NS3 47 (231–245) | 2 | 0 | 0 |
| NS3 51 (251–265) | 0 | 0 | 0 |
| NS3 61 (301–315) | 1 | 1 | 0 |
| NS3 68* (342–350) | 1 | 1 | 1 |
| NS3 100 (496–510) | 2 | 2 | 3 |
| NS3 106 (526–540) | 0 | 1 | 1 |
| NS3 108 (536–550) | 1 | 1 | 2 |
| NS3 111* (556–564) | 1 | 1 | 3 |
| NS3 120 (596–610) | 1 | 1 | 2 |
| NS4B 31 (151–165) | 1 | 1 | 2 |
| NS4B 39 (191–205) | 1 | 0 | 2 |
| NS5 24 (116–130) | 3 | 2 | 2 |
| NS5 33 (161–175) | 5 | 4 | 5 |
| NS5 59 (291–305) | 2 | 2 | 1 |
| NS5 61 (301–315) | 0 | 1 | 1 |
| NS5 66 (326–340) | 1 | 0 | 1 |
| NS5 69 (341–355) | 1 | 0 | 1 |
| NS5 78 (386–400) | 4 | 3 | 3 |
| NS5 113 (561–575) | 3 | 2 | 2 |
| NS5 152 (756–770) | 1 | 1 | 1 |
| NS5 176 (876–890) | 3 | 1 | 4 |
a
If the minimal epitope is known (indicated by an asterisk), the numbers refer to mutations within this portion. Otherwise, numbers refer to mutations within the 15mer peptide.