Table 2.

MHV-68 proteins tested for activity to antagonize ZAP

Protein name	Genome location (nt)	Protein		Possible functiona
		No. of amino acids	Mass (kDa)
ORF6	11216–14527	1,103	122	Single-stranded DNA binding protein
ORF9	19217–22297	343	41.2	DNA polymerase
ORF11	23488–24651	388	46.6	Virion protein
ORF18	29917–30768	284	34.1	Regulator of late-gene expression
ORF21	32879–34810	644	77.3	Thymidine kinase
ORF27	45329–46090	254	30.5	Glycoprotein
ORF33	49588–50568	327	39.2	Tegument protein
ORF38	55544–55768	75	9.0	Myristylated tegument protein
ORF40	57046–58875	610	73.2	Helicase-primase
ORF45	63655–64272	206	24.7	Tegument protein
ORF50 (RTA)	67907–69373	489	58.7	Transcriptional activator
ORF52	70960–71364	135	16.2	Tegument protein
ORF56	73289–75793	835	100.2	Helicase-primase
ORF57	76662–77159	166	19.9	Posttranscriptional regulator
ORF59	78258–79439	394	47.3	Processivity factor
ORF63	83751–86564	938	112.6	Tegument protein
ORF67	95738–96415	226	27.1	Tegument protein
ORF75b1	113901–111652	758	91.0	Tegument protein/FGARAT
ORF75a1	117904–115883	681	81.7	Tegument protein/FGARAT

^aFGARAT, N-formylglycinamide ribotide amidotransferase.