Table 2.
Molecular evolutionary rate and TMRCA for viruses belonging to each of the filovirus speciesa
| Species | Yr of first documented outbreak | TMRCA estimate (yr) | No. of yrs before the present for TMRCA estimate | Substitution rate (× 10−4 nucleotide substitutions/site/yr) |
|---|---|---|---|---|
| Zaire ebolavirus | 1976 | 1960 | 48 (32–65) | 7.06 (1.97–10.7) |
| Sudan ebolavirus | 1976 | 1173 | 838 (290–1,452) | 0.46 (0.14–0.78) |
| Reston ebolavirus | 1989 | 1979 | 30 (27–33) | 8.21 (7.30–9.18) |
| Taï Forest ebolavirus | 1994 | NA | NA | NA |
| Bundibugyo ebolavirus | 2007 | NA | NA | NA |
| Marburg marburgvirus | 1967 | 1302 | 707 (113–1,423) | 5.67 (0.49–8.97) |
a
TMRCA, time to most recent common ancestor. Values in parentheses are 95% highest posterior density (HPD) intervals.