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Proposed flow-chart for the laboratory diagnosis of MPS (dashed line indicates that test is optional for diagnosis). MPS - mucopolyssacaridosis; GAGs - glycosaminoglycans; LSDs - lysosomal storage diseases; DMB - Dimethyleneblue (method used for GAG quantitation); TLC - thin layer chromatography; EP - electrophoresis; WBC - white blood cells; DBS - dried blood spots.
