Table 1.
Results of Univariate and Multivariate Analyses of the Association Between Various Factors and Higher Human Immunodeficiency Virus (HIV) DNA Levels in Peripheral Blood Mononuclear Cells (PBMCs)
| Univariate Regression |
Multivariate Regression, All Samples |
|||||
|---|---|---|---|---|---|---|
| All Samplesa |
Matched Samplesb |
|||||
| Variable | Estimate (95% CI) | P | Estimate (95% CI) | P | Estimate (95% CI) | P |
| Presence of CMV in PBMCs | .26 (−.02 to .54) | .07 | .30 (−.01 to .61) | .06 | .28 (.001–.56) | .049 |
| Presence of CMV in semen | .17 (−.05 to .39) | .135 | .27 (.003–.55) | .048 | … | |
| Longer interval since HIV infection (mo) | .01 (−.001 to .02) | .083 | .004 (−.01 to .02) | .453 | .01 (−.00003 to .02) | .051 |
| HIV RNA load (log10 copies/mL) | .05 (−.09 to .20) | .481 | −.01 (−.19 to .16) | .873 | … | |
| CD4+ T-cell count (cells/mm3) | −.00 (.00–.00) | .482 | −.00 (.00–.00) | .529 | … | |
| 100% match with detection probe | .80 (.36–1.23) | <.001 | … | .83 (.39–1.27) | <.001 | |
Estimated slopes and 2-sided P values (α = 0.05) were calculated using linear mixed-effects models for repeated measures univariate and multivariate analysis. Univariate analysis was performed on all samples and on a subset of 159 samples with a complete match between the detection probe and the main viral population. All covariates with P values of < .10 in the univariate models were considered for multivariate modeling. The presence of CMV in semen was eliminated from our multivariate analysis since it was highly correlated with the presence of CMV in the cell (P < .0001).
Abbreviations: CI, confidence interval; CMV, cytomegalovirus.
a Data are for 113 subjects and 229 samples.
b Data are for 80 subjects and 159 samples.