Fig 9.
Model for the roles of Daxx in the initiation and maintenance of retroviral silencing. (Top) The role of Daxx as a scaffolding protein to recruit DNMTs and HDACs to viral DNA is depicted. (Bottom) Postintegration repressive epigenetic marks are depicted, along with Daxx, HDAC, and DNMTs. The mechanism by which Daxx is positioned on viral DNA during silencing maintenance is unknown, as indicated by the question mark.