Table 1.
Notation | Definition | Unit | Value | Reference(s) |
---|---|---|---|---|
State variables | ||||
G | Concentration of full-length dimerized HIV genomic mRNAs | 1/μl | ||
GDIP | Concentration of full-length dimerized DIP genomic mRNAs | 1/μl | ||
C | Concentration of encapsidation-competent capsids in cytoplasm | 1/μl | ||
m | DIP (integrated) provirus copy number (i.e., MOI) | Dimensionless | ||
Model parameters | ||||
θ | Rate of accumulation of encapsidation-competent HIV genomes in cytoplasm | 1/μl/day | ||
kpck | Packaging constant | μl/day | ||
α | Loss of genome rate | 1/day | ||
β | Loss of capsid rate | 1/day | ||
η | Capsid-to-genome accumulation ratio | Dimensionless | 1.2 to 5 | 10 and 72 |
P | Expression asymmetry between DIP and HIV | Dimensionless | 8 to 10 | 13 |
See Fig. 2A and equations 1 to 3.