Fig 2.
The extent of suppression by spleen cells from LP-BM5-infected mice correlates with the published degree of LP-BM5-induced disease exhibited by the indicated mouse strain of origin for the suppressor cells. (A) A [3H]thymidine incorporation assay was used to assess the B- and T-cell proliferation during a 3-day culture of responder cells mixed with nonfractionated spleen cells from the indicated strains of 5-w.p.i. LP-BM5-infected mice. The presented pattern of results is representative of two additional experiments. (B) R/S titrations (with decreasing numbers of suppressor cells) are included, and the presented pattern of results is representative of one additional experiment. Significance levels: *, P < 0.05; **, P < 0.01; ***, P < 0.001; and ****, P < 0.0001.