Table 3.
Bivariate Relationships of Demographic and Clinical Variables to Time to Recurrence in 152 Older Subjects with Major Depression Who Remained in Remission Past the Risk Period for Relapse.
| Variables | Cox Proportional Hazards Model | ||
|---|---|---|---|
| Hazard Ratio (95% CI) | Wald χ2 | p | |
| Age | 1.01 (0.97–1.06) | 0.22 | 0.64 |
| Education | 0.99 (0.90–1.09) | 0.04 | 0.83 |
| Gender | 1.60 (0.83–3.11) | 1.97 | 0.16 |
| Outpatient/Inpatient Status at Entry | 1.41 (0.95–2.08) | 2.91 | 0.08 |
| Duration Subsyndromal Symptoms | 1.16 (1.08–1.24) | 18.28 | <.0001 |
| Duration of Index MDD Episode | 1.00 (1.00–1.06) | 2.85 | 0.09 |
| Age at Onset of MDD | 1.00 (0.99–1.02) | 0.57 | 0.45 |
| Number MDD Episodes | 0.97 (0.94–1.29) | 0.16 | 0.69 |
| At Entry | |||
| DRS Total1 | 1.03 (0.99–1.08) | 1.80 | 0.18 |
| CIRS Total2 | 1.07 (0.97–1.18) | 1.77 | 0.18 |
| IADL3 | 0.95 (0.84–1.10) | 0.39 | 0.53 |
| At Onset of Remission | |||
| DRS Total1 | 1.02 (0.97–1.07) | 0.51 | 0.48 |
| CIRS Total2 | 0.98 (0.88–1.09) | 0.15 | 0.70 |
| IADL3 | 1.07 (0.89–1.29) | 0.44 | 0.51 |
| Intensity of AD Treatment4 | 1.12 (0.85–1.47) | 0.62 | 0.43 |
| Intensity of AD Treat X Time§ | 1.23 (1.03–1.46) | 5.41 | 0.02 |
§
Time=log(time to recurrence)-5.69; The constant, 5.69, is the average of the logs of the survival times. The hazard ratio of Intensity of AD Treatment scores was not proportional over time as shown by the significant Intensity of AD Treat x Time interaction
1
Mattis Dementia Rating Scale
2
Cumulative Illness Rating Scale-Geriatric Version
3
Philadelphia Multilevel Assessment Instrument – IADL Subscale
4
Composite Antidepressant Score (CAD) in last month before recurrence or before last follow-up.