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. Author manuscript; available in PMC: 2013 Feb 13.
Published in final edited form as: Gynecol Oncol. 2009 Sep 22;115(3):362–366. doi: 10.1016/j.ygyno.2009.08.028

Figure 1.

Figure 1

Pt concentration per tumor as a function of tumor wet weight. A. Natural log of Pt concentration in each tumor vs. natural log tumor wet weight, by treatment group. Regression lines were estimated from a mixed model containing a random intercept for each mouse. DDP 10 mg/kg group: solid line, open triangle; estimated slope −0.26 units ln(Pt concentraion) per unit ln(tumor weight); 95% CI on slope −0.38,−0.13. CBDCA 85 mg/kg group: heavy dashed line, ‘+’; estimated slope 0.03; 95% CI on slope −0.04, 0.09. CBDCA 12.4 mg/kg group: dotted line, open circle; estimated slope −0.08; 95% CI on slope −0.13, −0.03. On the original scale, the estimated slope for DDP corresponds to a statistically significant 16.5% decrease in Pt concentration for each doubling of tumor weight, for CBDCA 85 mg/kg, a non-significant increase in Pt concentration as tumor weight increases (by 5.7% for each doubling of tumor weight) and a small but statistically significant 5.3% decrease in Pt for each doubling of weight for CBDCA 12.4 mg/kg.