Table 1.

Tumor characteristics and mean platinum uptake, by dose group

Drug	Dose, mg/kg	No. tumors analyzed	Median no. tumors per mouse(range)	Median tumor length in mm(range)	Median tumor width in mm(range)	Mean† tumor volume in mm3(95% CI)*	Mean† tumor wet weight in mg(95% CI)*	Mean† tumor platinum in ng Pt/mg tumor weight(95% CI)*
DDP	10	129a	19.0 (2–23)	4 (2–11)	3 (2–10)	16.2 (11.5–22.8)	15.1 (12.3–18.6)	1.92 (0.85, 4.32)
CBDCA	12.4	384b	34.0 (1–60)	4 (2–22)	3 (1–12)	14.0 (10.8–18.1)	16.6 (14.3–19.3)	0.57 (0.29, 1.11)
CBDCA	85	236c	18.5 (6–45)	4 (1–20)	2 (1–9)	10.3 (7.8–13.5)	16.2 (13.8–19.0)	2.47 (1.28, 4.79)

^an=9 mice,

^bn=12 mice,

^cn=12 mice,

^*=p>0.05, DDP=cisplatin, CBDCA=carboplatin, Pt=platinum.

^†Means and standard errors were calculated from log-transformed data using a random intercept model; values reported here are exponentiated model estimates and so estimate the geometric mean.