Table 2.
Genotype distribution. P value is calculated by Chi-square test with 1 degree of freedom based on allelic frequency.
| Gene | Genotype | EA# | AA | Allele | EA | AA | P value |
|---|---|---|---|---|---|---|---|
| ERCC1‡ N118N (500C>T) |
CC CT TT TOTAL |
23(0.21)* 53(0.49) 32(0.30) 108 |
96(0.76) 27(0.21) 4(0.03) 127 |
C T TOTAL |
99(0.46) 117(0.54) 216 |
219(0.86) 35(0.14) 254 |
<0.000001 |
| ERCC1 C8092A |
CC AC AA TOTAL |
77(0.53) 59(0.40) 10(0.07) 146 |
74(0.52) 56(0.40) 11(0.08) 141 |
C A TOTAL |
213(0.73) 79(0.27) 292 |
204(0.72) 78(0.28) 282 |
0.870913 |
| ERCC2 K751Q (2282A>C) |
AA AC CC TOTAL |
49(0.42) 56(0.47) 13(0.11) 118 |
81(0.56) 57(0.40) 6(0.04) 144 |
A C TOTAL |
154(0.65) 82(0.35) 236 |
219(0.76) 69(0.24) 288 |
0.006675 |
| XRCC1 R399Q (1301G>A) |
GG AG AA TOTAL |
49(0.46) 47(0.44) 10(0.10) 106 |
113(0.80) 26(0.19) 2(0.01) 141 |
G A |
145(0.68) 67(0.32) 212 |
252(0.89) 30(0.11) 282 |
<0.00000l |
| XRCC1 R194W (685C>T) |
CC CT TT TOTAL |
120(0.87) 17(0.12) 1(0.01) 138 |
133(0.90) 14(0.09) 1(0.01) 148 |
C T TOTAL |
257(0.93) 19(0.07) 276 |
280(0.95) 16(0.05) 296 |
0.460941 |
| PARP1 V762A (2446T>C) |
TT CT CC TOTAL |
80(0.67) 32(0.27) 7(0.06) 119 |
108(0.91) 11(0.09) 0(0) 119 |
T C TOTAL |
192(0.81) 46(0.19) 238 |
227(0.95) 11(0.05) 238 |
0.000001 |
‡
Indicates: gene name, amino acid change and position, nucleotide change and the position.
#
EA: Americans of European descent, AA: Americans of African descent.
*
Indicates: Count (frequency).