Figure 6.
(A) Expanded region of the two-dimensional {1H,15N} HSQC spectra of delipidated ApolPBP1ΔP129-V142 (220 μM) in 50mM phosphate buffer, pH 6.5, upon titration with palmitic acid. Protein: ligand ratios are indicated in the figure. Note the disappearance of the resonance belonging to Gly13 due to line broadening. Some other resonances are in intermediate-to-fast exchange regime. (B) Resonance corresponding to Leu68 showing the phenomenon of intermediate exchange, from the same spectrum as in (A). (C) One-dimensional slices from the 1H axis taken in the midpoint of the resonance corresponding to Leu68 (same as in (B)) showing the intermediate exchange phenomenon. Protein: ligand ratios are indicated on top of each slice. All slices are scaled relative to the same y axis.