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Schematic representation of the role of C-terminus in ligand binding and release mechanism in ApolPBP1. The ligand-bound wild type protein (in open conformation) at physiological pH undergoes a pH dependent conformational change to release ligand at acidic pH (closed conformation). The C-terminus truncated protein, however, remains in the open conformation at both physiological and acidic pH, in the presence/absence of ligand.
