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. 2012 Oct 8;10:85. doi: 10.1186/1477-7827-10-85

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Copyright ©2012 van Diepen; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mean urinary change in sodium/potassium (Δ[Na⁺]/[K⁺]) ratio in rats after oral administration of (A) spironolactone (SP), nomegestrol acetate (NOMAC), or nomegestrol (NOM); (B) SP, 17β-estradiol (E2), or NOMAC/E2; and (C) SP, drospirenone (DRSP), ethinyl estradiol (EE), or NOMAC/EE. t₁, overnight urine; t₃, urine collected during last time. Doses are in mg/kg. Results are shown as mean ± standard error of the mean. * P<0.05; ** P<0.01 indicates the results were statistically significant compared with placebo-treated animals (analysis of variance).