Table 1.
Effect of progesterone, MPA, and NOMAC on the uterine weight in estradiol-benzoate-treated mice
| Estradiol benzoate | Progestogen |
Dose |
No. of mice | Uterine weight |
|---|---|---|---|---|
| (mg/mouse/3 days) | ||||
|
Subcutaneous administrationa | ||||
| – |
– |
– |
20 |
21.61 ± 1.37** |
| 0.1 |
– |
– |
10 |
32.88 ± 2.26 |
| 0.1 |
Progesterone |
0.3 |
5 |
32.04 ± 1.38 |
| 0.1 |
0.6 |
5 |
30.46 ± 1.53 |
|
| 0.1 |
0.9 |
5 |
29.78 ± 2.99 |
|
| 0.1 |
MPA |
0.3 |
5 |
27.50 ± 1.08 |
| 0.1 |
0.6 |
5 |
24.92 ± 2.37* |
|
| 0.1 |
0.9 |
5 |
29.34 ± 2.42 |
|
| 0.1 |
NOMAC |
0.3 |
5 |
27.16 ± 3.22 |
| 0.1 |
0.6 |
5 |
23.72 ± 1.08** |
|
| 0.1 |
0.9 |
5 |
23.94 ± 1.16** |
|
|
Oral administrationa | ||||
| – |
– |
– |
40 |
12.31 ± 0.49 |
| 0.1 |
– |
– |
31 |
40.99 ± 2.11 |
| 0.1 |
MPA |
0.3 |
8 |
30.08 ± 3.92* |
| 0.1 |
0.6 |
7 |
22.39 ± 3.09** |
|
| 0.1 |
0.9 |
8 |
24.70 ± 2.27** |
|
| 0.1 |
NOMAC | 0.1 |
9 |
46.74 ± 4.48 |
| 0.1 |
0.3 |
16 |
29.22 ± 1.89** |
|
| 0.1 |
0.6 |
28 |
30.97 ± 2.47** |
|
| 0.1 |
0.9 |
16 |
25.07 ± 2.28** |
|
| 0.1 | 1.8 | 9 | 25.09 ± 4.37** | |
Uterine weights (mg) are expressed as the mean ± standard deviation.
aEstradiol-benzoate was administered as a subcutaneous injection. MPA, medroxyprogesterone acetate. * P<0.01; ** P<0.001 compared with the estradiol-benzoate-treated control group.