Table 2.
Effect of progesterone, NOMAC, and MPA on the pituitary-adrenal axis in OVX rats
| Treatment | Dose (mg/rat/day) | Rats (n) | Adrenal weight (mg) |
|---|---|---|---|
| Control (No OVX) |
– |
16 |
46.59 ± 1.51* |
| Control (OVX) |
– |
28 |
53.32 ± 1.63 |
| Progesterone (OVX) |
10 |
10 |
39.98 ± 2.15* |
| NOMAC (OVX) |
0.3 |
10 |
58.38 ± 3.53 |
| 1 |
19 |
60.28 ± 1.89* |
|
| 3 |
9 |
59.43 ± 2.03* |
|
| MPA (OVX) | 0.1 |
8 |
47.28 ± 2.66* |
| 0.3 |
10 |
37.35 ± 1.77* |
|
| 1 |
8 |
27.58 ± 1.15* |
|
| 3 | 8 | 20.86 ± 1.14* |
Adrenal weight is shown as the mean ± the standard error of the mean.
ANOVA, analysis of variance; MPA, medroxyprogesterone acetate; NOMAC, nomegestrol acetate; OVX, ovariectomized.
* P<0.05 vs OVX control (ANOVA).