Table 3.
Effect of hydrocortisone, NOMAC, and MPA on inflammatory response
| Treatment | Dose (mg/kg) | Adrenal weight (mg) | Thymus weight (mg) | Granuloma weight (mg) |
|---|---|---|---|---|
| Vehicle |
– |
38.8 ± 1.4 |
607 ± 34 |
29.7 ± 1.5 |
| Hydrocortisone |
10 |
28.6 ± 1.1* |
355 ± 42* |
24.6 ± 1.4* |
| 80 |
25.0 ± 0.9* |
139 ± 15* |
22.0 ± 1.4* |
|
| NOMAC |
2.5 |
36.2 ± 2.1 |
614 ± 43 |
23.3 ± 1.4* |
| 5 |
35.8 ± 1.7 |
586 ± 28 |
27.1 ± 2.5 |
|
| 10 |
36.7 ± 1.0 |
576 ± 46 |
26.4 ± 1.6 |
|
| MPA | 2.5 |
32.4 ± 1.0* |
636 ± 25 |
25.4 ± 1.7 |
| 5 |
30.4 ± 1.5* |
624 ± 42 |
25.8 ± 2.1 |
|
| 10 | 24.2 ± 1.4* | 512 ± 20* | 24.6 ± 1.9* |
Sample weights (mg) are shown as the mean ± standard error of the mean. ANOVA, analysis of variance; MPA, medroxyprogesterone acetate; NOMAC, nomegestrol acetate; * P<0.05 compared with the vehicle control group (ANOVA).