Table 2.

Univariate log-rank analyses for disease-specific, metastasis-free, and urinary bladder recurrence-free survival

Parameter		No. of cases	Disease-specific survival		Metastasis-free survival		UB Recurrence-free survival
			No. of events	pvalue	No. of events	pvalue	No. of events	pvalue
Gender	Male	158	28	0.8286	32	0.7904	43	0.0369*
	Female	182	33		38		36
Age (years)	<65	138	26	0.9943	30	0.8470	34	0.5107
	≥65	202	35		40		45
Tumor side	Right	177	34	0.7366	38	0.3074	44	0.6047
	Left	154	26		32		32
	Bilateral	9	1		0		3
Tumor location	Renal pelvis	141	24	0.0079*	31	0.0659	33	0.1723
	Ureter	150	22		25		32
	Renal pelvis and ureter	49	15		14		14
Multifocality	Single	273	48	0.0026*	52	0.0127*	64	0.1861
	Multifocal	62	18		18		15
Primary tumor (T)	Ta ~ T1	181	11	<0.0001*	19	<0.0001*	43	0.2688
	T2 ~ T4	159	50		51		36
Nodal metastasis	Negative (N0)	312	42	<0.0001*	55	<0.0001*	73	0.1422
	Positive (N1 ~ N2)	28	19		15		6
Histological grade	Low grade	56	4	0.0215*	3	0.0027*	14	0.0056*
	High grade	284	57		67		65
Pattern of invasion	Non-invasive/nodular	200	19	<0.0001*	27	<0.0001*	50	0.5398
	Trabecular	58	12		13		14
	Infiltrative	82	30		30		15
Vascular invasion	Absent	234	24	<0.0001*	26	<0.0001*	55	0.1770
	Present	106	37		44		24
Perineurial invasion	Absent	321	50	<0.0001*	61	<0.0001*	75	0.2169
	Present	19	11		9		4
Mitotic rate (per 10 high power fields)	<10	173	27	0.1607	30	0.0823	43	0.9031
	≥10	167	34		40		36
Adjuvant chemotherapy	Not performed	311	54	0.4084	61	0.2151	70	0.2740
	Performed	29	7		9		9
HuR cytoplasmic expression	Low	170	13	<0.0001*	19	<0.0001*	33	0.0370*
	High	170	48		51		46
Cyclin A expression	Low	170	19	0.0035*	22	0.0015*	36	0.3784
	High	170	42		48		43

* Statistically significant.