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. 2012 Dec 21;12:611. doi: 10.1186/1471-2407-12-611

Table 3.

Multivariate analyses of disease-specific, metastasis-free, and urinary bladder recurrence-free survival

Variable Category Disease-specific survival
 Metastasis-free survival
 UB Recurrence-free survival
Relative risk 95% Confidence interval pvalue Relative risk 95% Confidence interval pvalue Relative risk 95% Confidence interval pvalue
Nodal metastasis
 Positive vs. negative
 5.602
 2.912 ~ 10.776
 <0.001*
 3.174
 1.648 ~ 6.115
 0.001*
 -
 -
 -
Perineurial invasion
 Present vs. absent
 3.291
 1.522 ~ 7.117
 0.002*
 2.460
 1.120 ~ 5.401
 0.025*
 -
 -
 -
Multifocality
 Multifocal vs. single
 2.816
 1.321 ~ 6.004
 0.007*
 2.408
 1.124 ~ 5.158
 0.024*
 -
 -
 -
Pattern of invasion
 Infiltrative vs. trabecular vs. non-invasive/Nodular
 1.596
 1.090 ~ 2.337
 0.016*
 1.307
 0.906 ~ 1.885
 0.152
 -
 -
 -
Histological grade
 High grade vs. low grade
 3.751
 1.170 ~ 12.024
 0.026*
 4.187
 1.221 ~ 14.364
 0.023*
 2.113
 1.173-3.805
 0.013*
HuR Cyto. Exp.†
 High vs. low
 1.996
 1.039 ~ 3.834
 0.038*
 1.880
 1.074 ~ 3.291
 0.027*
 1.398
 0.886-2.204
 0.150
Vascular invasion
 Present vs. absent
 1.549
 0.823 ~ 2.913
 0.175
 2.872
 1.486 ~ 5.550
 0.002*
 -
 -
 -
Cyclin A expression
 High vs. low
 1.632
 0.909 ~ 2.932
 0.101
 1.703
 0.994 ~ 2.918
 0.053
 -
 -
 -
Primary tumor (T)
 T2 ~ T4 vs. Ta ~ T1
 1.412
 0.586 ~ 3.400
 0.442
 0.916
 0.419 ~ 2.003
 0.826
 -
 -
 -
Tumor location
 Both renal pelvis and ureter vs. one location alone
 0.950
 0.614 ~ 1.471
 0.819
 0.786
 0.572 ~ 1.340
 0.541
 -
 -
 -
Mitotic rate
 ≥10 vs. <10/10 hpf
 -
 -
 -
 0.849
 0.514 ~ 1.402
 0.523
 -
 -
 -
Gender Male vs. female - - - - - - 1.607 1.030-2.507 0.036*

† Cyto. Exp., cytoplasmic expression. * Statistically significant.