Table 2. Proteins mapped to primary canonical pathways enriched in the HEV ORF3 and human protein interaction network.

Canonical pathways*	Description	Proteins
BIOCART	Prothrombin activation pathway	FGA,FGB,SERPINC1,SERPING1
	Fibrinolysis pathway	FGA,FGB
KEGG	Complement and coagulation cascades	FGA,FGB,SERPINC1,SERPING1
	Oxidative phosphorylation	COX2, NDUFS2
REACTOME	Genes involved in formation of fibrin clot (clotting cascade)	FGA,FGB,SERPINC1,SERPING1
	Genes involved in platelet activation, degranulation and formation of platelet plug	FGA,FGB,SERPING1, TF, CD63
	Genes involved in Grb2:SOS provides linkage to MAPK signaling for intergrins	CYP2E1,NR0B2
	MAPK signaling for intergrins	FGA,FGB
	Integrin cell surface interactions	FGA,FGB,VTN
	Biological oxidations	CYP2E1, NAT1, MAT1A

^*Canonical pathways include the Biocart pathway database, KEGG pathway database, Reactome pathway database.