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. 2013 Feb 13;8(2):e56267. doi: 10.1371/journal.pone.0056267

Table 1. Hemodynamic and respiratory variables in Responder and Non-Responder before and after fluid loading during baseline and pleural effusion.

Responder n = 6 Non-Responder n = 5
Variable BL - NV PLE - NV BL - FL PLE - FL BL - NV PLE – NV BL - FL PLE - FL
HR (min −1 ) 123±15 138±23 1105 13421 11417 14423* , # 10917 13227
MAP (mmHg) 594 56±5 82±7a 82±3a,c 76±3 64±7 93±2* , Δ 87±4* , Δ
SVR (dyne•s/cm5) 892±225 1022±100 1155±245 1321±307a 960±174 1065±277 1173±173 1317±272*
CL (ml cmH2O −1 ) 41±10 18±4a,b 39±9c 16±4a,b 38±13 16±4* , # 32±10Δ 15±3* , #
CCW (ml cmH2O −1 ) 87±19 94±24 82±10 89±24 94±4 171±80* , # 897Δ 126±46#
dPes (cmH2O) 8.0±1.4 12.9±5.7a,b 9.0±1.4c 13.3±1.4a,b 5.7±1.5 13.2±4.9* , # 7.0±2.9 13.5±3.1*
Ptp,es (cmH2O) 9.8±3.7 13.7±3.8a,b 8.3±3.9 14.3±4.6a,b 10.7±4.0 14.2±4.3* , # 8.5±4.7 15.8±3.1* , #
PAW peak (cmH2O) 24±3 36±3a,b 24±3c 39±4a,b 25±4 40±5* , # 26±3Δ 41±4* , #
PAW mean (cmH2O) 12±2 15±1 12±2 15±1 12±1 16±1 12±1 16±1
VT (ml) 350±56 344±57 343±49 334±42 347±42 341±46 340±48 337±47
PEEP (cmH2O) 5.1±2.4 5.9±0.5 5.2±2.3 5.1±1.4 5.8±0.9 5.2±0.4 5.5±1.3 5.1±0.5
COPAC (l min −1 ) 5.1±0.7 3.9±0.7a,b 6.2±0.4a,c 5.3±1.1b,c 6.2±1.2 4.0±0.9* , # 6.5±1.8Δ 4.1±1.3* , #
SVPAC (ml min −1 ) 45.2±4.7 30.8±8.3a,b 52.3±5.1a 41.7±9.1b,c 52.3±8.2 31.5±8.9* , # 53.8±7.4Δ 31.2±9.7* , #
CVP (mmHg) 7.2±2.8 12.0±3.4a 9.2±3.2 13.3±2.6a,b 7.5±5.7 10.8±2.6 10.2±5.8 12.8±2.7*
PAOP (mmHg) 10.3±2.3 13.3±1.6a 12.5±2.3 15.7±2.9a 10.0±5.3 15.0±4.6* 13.0±4.5 16.2±1.9* , #
PPV (%) 15.6±3.7 20.6±8.2b 11.0±1.7a,c 10.7±5.3a,c 8.6±3.1 9.4±7.1# 10.0±2.6Δ 14.0±7.7* , #
SVV (%) 13.7±5.3 17.5±6.9 10.7±3.2 c 10.4±3.1c 8.2±2.9 9.5±4.7# 9.4±3.9 12.5±3.7* , #
GEDV (ml) 635±61 496±87b 694±43a,c 591±83b 743±93 641±87* , # 764±82* , Δ 715±103Δ

BL - NV, baseline normovolemia; PLE - NV, pleural effusion normovolemia; BL - FL, baseline fluid loading; PLE - FL, pleural effusion fluid loading; HR, heart rate; MAP, mean arterial pressure; SVR, systemic vascular resistance; CL, lung compliance; CCW, chest wall compliance; dPes, delta esophageal pressure; Ptp,es, transpulmonary pressure measured with an esophageal balloon; PAW peak, end-inspiratory airway pressure; PAW mean, mean airway pressure; VT, tidal volume; PEEP, positive end-expiratory pressure; COPAC, cardiac output derived from pulmonary thermodilution; SVPAC, stroke volume derived from pulmonary thermodilution; CVP, central venous pressure; PAOP, pulmonary artery occlusion pressure; PPV, pulse pressure variation; SVV, stroke volume variation; GEDV, global end-diastolic volume; Values are given as mean ±SD; Responder:

a

p<0.05 (vs. BL - NV);

b

p<0.05 (vs. BL - FL);

c

p<0.05 (vs. PLE – NV); Non-Responder:

*

p<0.05 (vs. BL - NV);

#

p<0.05 (vs. BL - FL);

Δ

p<0.05 (vs. PLE – NV).