Table 2. Univariate analysis of clinicopathological features and autophagy marker expression in relation nto patient overall survival (OS) (n = 178).
| Parameter | 5-y OS % | Hazard Ratio (95% CI) | P-value§ |
|---|---|---|---|
| Age (1-y increase) | NA | 1.02 (0.99, 1.04) | 0.1624 |
| Gender | 0.8699 | ||
|---|---|---|---|
| Female |
72% |
- |
|
| Male | 69% | 1.04 (0.64, 1.69) |
| TNM Stage | 0.0161 | ||
|---|---|---|---|
| II |
91% |
- |
|
| III | 66% | 2.70 (1.16, 6.25) |
| Grade | 0.0074 | ||
|---|---|---|---|
| I/II |
76% |
- |
|
| III/IV | 59% | 1.91 (1.18, 3.10) |
| Tumor Site | 0.8402 | ||
|---|---|---|---|
| Distal |
72% |
- |
|
| Proximal | 68% | 0.95 (0.58, 1.55) |
| Beclin 1† | 0.0540 | ||
|---|---|---|---|
| Low |
79% |
- |
|
| High | 68% | 1.78 (0.98, 3.24) |
| p62/SQSTM 1† | 0.7679 | ||
|---|---|---|---|
| Low |
69% |
- |
|
| High | 72% | 0.91 (0.47, 1.74) |
| LC3† | 0.3877 | ||
|---|---|---|---|
| Low |
70% |
- |
|
| High | 73% | 0.74 (0.38, 1.46) |
§ Score test p-value from a Cox Regression model after stratifying by study; †Missing data for Beclin 1 (n = 12); p62 (n = 7); LC3 (n = 43).