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Figure 2. Effects of dasatinib and sunitinib on Cav-1 expression and secretion and on TK signaling in DU145 cells. Dasatinib (A) and sunitinib (B) treatment of DU145 cells resulted in a dose-dependent decrease in phosphorylation of PDGFRβ, VEGFR2, Src and Cav-1. Dasatinib, but not sunitinib, also reduced the phosphorylation of FAK and Akt. Both dasatinib and sunitinib dose-dependently reduced significantly the secretion of Cav-1.
