Figure 4. Antitumor activity of dasatinib (Dasa) in combination with anti-Cav-1 antibody (Cav-1 Ab) on PC-3 xenografts in nude mice. (A) Dasatinib alone and anti-Cav-1 antibody alone significantly reduced the tumor volume of PC-3 cells growing as xenografts compared with those of vehicle- and IgG-treated controls (p = 0.002 and p = 0.02, respectively). Anti-Cav-1 antibody treatment also enhanced the efficacy of dasatinib. Each data point represents the mean tumor volume in each group containing 9–16 mice (B), dasatinib alone and anti–Cav-1 antibody alone significantly reduced the tumor wet weight in nude mice bearing PC-3 tumor xenografts compared with the weights in vehicle- and IgG-treated controls (p = 0.0072 and p = 0.0307, respectively). Data represents the mean tumor weight ± SEM in each group containing 9–16 mice.