Figure 5. Antitumor activity of sunitinib (Suni) alone and in combination with anti–Cav-1 antibody (Cav-1Ab) on DU145 xenografts in nude mice. (A) Sunitinib alone and anti-Cav-1 antibody alone significantly reduced the tumor volume of DU145 cells growing as xenografts compared with those of vehicle- and IgG-treated controls (p = 0.0015 and p = 0.0377, respectively). Anti-Cav-1 antibody treatment also enhanced the efficacy of sunitinib. Each data point represents the mean tumor volume in each group containing 7–10 mice. (B) Sunitinib alone and anti-Cav-1 antibody alone significantly reduced the tumor wet weight in nude mice bearing DU145 tumor xenografts compared with those in vehicle- and IgG-treated control mice (p = 0.0004 and p = 0.0016, respectively). Data represents the mean tumor weight ± SEM in each group containing 7–10 mice.