Phloretin
|
GLUT1
|
Blocks glucose uptake
|
Fasentin
|
GLUT1
|
Blocks glucose uptake
|
2-Deoxyglucose
|
Hexokinase
|
Blocks glycolytic flux
|
3-Bromopyruvate
|
Hexokinase
|
Blocks glycolytic flux
|
Clotrimazole
|
Hexokinase
|
Blocks glycolytic flux
|
Iodoacetate
|
G3PDH
|
Blocks glycolytic flux
|
Fluoride
|
enolase
|
Blocks glycolytic flux
|
FX11
|
Lactate dehydrogenase
|
Blocks metabolic flux
|
Dichloroacetate
|
Pyruvate dehydrogenase kinase
|
Promotes oxidative phosphorylation
|
PKM2 inhibitor
|
Pyruvate kinase 2
|
Prevents ATP production in hypoxia cancer cells
|
PKM2 activator
|
Pyruvate kinase 2
|
Promotes oxidative cellular damage in oxygenated cancer cells
|
Buthionine S′R′-sulfoximine
|
G6PD
|
Inhibits oxidative PPP pathway
|
6-aminonicotinamide
|
G6PD
|
Inhibits oxidative PPP pathway
|
Chloroquine
|
autophagy
|
Cuts off stromal fuel supply
|
Metformin
|
Energy sensing pathways(AMPK)
|
Inhibits lipolysis and oxidative phosphorylation
|
C93
|
FASN
|
Inhibits fatty acid synthesis
|
FAS31
|
FASN
|
Inhibits fatty acid synthesis
|
Rotenone
|
Mitochondrial respiration complex I
|
Inhibits oxidative phosphorylation
|
α-TOS
|
Mitochondrial respiration complex II
|
Genarates reactive oxygen species
|
Benzylisothiocyanate
|
Mitochondrial respiration complex Ш
|
Genarates reactive oxygen species
|
Oligomycin
|
Mitochondrial respiration complex IV
|
Inhibits ATP synthesis
|
Resveratrol
|
Mitochondrial respiration complex IV
|
Inhibits ATP synthesis
|
L-asparaginase
|
Glutamine uptake
|
Depletes blood glutamine level
|
L-γ-glutamyl-p-nitroanilide (GPNA)
|
SLC1A5 (a target of Myc)
|
Inhibits glutamine uptake and inhibits mTOR activation
|
968
|
Glutaminase
|
Inhibits Rho GTPases
|
| Aminoxyacetic acid (AOA) |
Glutamine aminotransferase |
Inhibits transamination |
