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. 2013 Feb 13;8(2):e56334. doi: 10.1371/journal.pone.0056334

Figure 4. Network visualization of AML-relevant pathways enriched in the four human Argonaute proteins.

Figure 4

Ago-protein associated mRNAs (bubbles) were mapped on KEGG signaling pathways (blue edges) in (A) KASUMI-1 and in (B) NB4 cell lines. Depicted mRNAs are enriched in the Ago-protein compared to the isotype control in triplicate experiments and were among the top enriched pathways. Bubble sizes illustrate the amount of detected mRNAs as signal intensities in light units (LU). The bubble-colors represent the different Ago-proteins in which the distinct mRNA was identified. miRNA binding sites were identified using TargetScan, PicTar and miRanda (green edges). miRNAs with sequence similarity are summarized in sequence groups (seqgrp).